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Pharmacological properties of kamagra

Kamagra is rapidly absorbed. The maximum concentration observed vplazme ranging from 30 to 120 minutes (median 60 minutes) poslepriema fasting. While receiving sildenafil with fatty foods, stepenvsasyvaniya greatly reduced, the average delay in terms Tmaxna 60 minutes and an average reduction popokazatelyu Cmax by 29%. The average volume of distribution at steady state (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil iego major circulating metabolite N-desmethyl metabolite is approximately 96% bound to plasma proteins. Plasma protein binding is independent of drug obscheykontsentratsii.

The drug is mainly derived pechenochnymimikrosomalnymi isoenzymes CYP 3A4 (major pathway) and CYP2C9 (minor pathway). Is converted to the active metabolite by N-desmetilirovaniyai then further metabolized. This metabolite has analogichnoyselektivnostyu against PDE and in vitro activity against PDE-5 ~ 50% of the parent drug.

Sildenafil derived primarily as metabolites sfekaliyami (~ 80%) and to a lesser extent in the urine (~ 13%).

pharmacodynamics

Kamagra contains a part of the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP) - spetsificheskoyfosfodiesterazy type 5 (PDE5) .Fiziologichesky mechanism of erection of the penis involves the release of okisiazota (OA) in the corpus cavernosum of the penis during sexual vozbuzhdeniya.Zatem nitric oxide activates the enzyme guanylate cyclase that leads to uvelicheniyuurovney cyclic guanosine monophosphate (cGMP), providing relaxation in the corpus cavernosum gladkoymyshtsy and ensuring the flow of blood. The drug has no effect on pryamymrelaksatsionnym cavernous body of a person, but strengthens deystvieokisi nitrogen (OA) by inhibiting phosphodiesterase type 5 (PDE5), kotorayaotvechaet for the breakdown of cGMP in the corpus cavernosum. When seksualnomvozbuzhdenii occurs when local release of OA, inhibition of PDE5 preparatomvyzyvaet increase in the level of cGMP in the corpus cavernosum of the penis, resulting in smooth muscle krasslableniyu and streams of blood to the cavernous body. Kamagra does not cause an erection in the absence of sexual stimulation.

Sildenafil derived primarily as metabolites sfekaliyami (~ 80%) and to a lesser extent in the urine (~ 13%).

pharmacodynamics

Kamagra Oral Jelly contains a part of the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP) - spetsificheskoyfosfodiesterazy type 5 (PDE5) .Fiziologichesky mechanism of erection of the penis involves the release of okisiazota (OA) in the corpus cavernosum of the penis during sexual vozbuzhdeniya.Zatem nitric oxide activates the enzyme guanylate cyclase that leads to uvelicheniyuurovney cyclic guanosine monophosphate (cGMP), providing relaxation in the corpus cavernosum gladkoymyshtsy and ensuring the flow of blood. The drug has no effect on pryamymrelaksatsionnym cavernous body of a person, but strengthens deystvieokisi nitrogen (OA) by inhibiting phosphodiesterase type 5 (PDE5), kotorayaotvechaet for the breakdown of cGMP in the corpus cavernosum. When seksualnomvozbuzhdenii occurs when local release of OA, inhibition of PDE5 preparatomvyzyvaet increase in the level of cGMP in the corpus cavernosum of the penis, resulting in smooth muscle krasslableniyu and streams of blood to the cavernous body. Kamagra vrekomenduemyh doses does not cause an erection in the absence of sexual stimulation.


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